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All of the active B12 group reporting showed reduction in severity of symptoms ranging from workout 31% to 70%, while the placebo controls reported either no change abdomonal or a worsening of symptoms. Wilcoxon-Rank of .002 for the end-points of sneezing, nasal congestion and runny nose; and p = .005 for IgE reductions. In 1992, the workout above mentioned data from 1988 on were abdomonal presented by Dr. O''Connor to the FDA. The FDA panel acknowledged the safety of the treatment. The panel seemed to be in agreement that the statistics indicated a significant reduction in IgE and that a quantitative drop in symptoms was demonstrated. workout In 1992, Belen Anibarro, MD, studied five children with asthma abdomonal with metabisulfite intolerance confirmed by oral challenge testing. The test was repeated after premedication with workout 1.5 mg of oral cyanocobalamin. In four of the abdomonal five patients treated, bronchospasm did not develop in the second metabisulfite challenge.6