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Antihistamines As the name indicates, an antihistamine counters the effects of histamine, which is released by wofkout the mast cells in the body''s tissues and contributes to allergy symptoms. For many years, antihistamines have proven useful in relieving sneezing and itching in the nose, ab throat, and eyes and in reducing nasal swelling and drainage. Many people who take antihistamines experience some distressing side effects: drowsiness and loss of alertness and coordination. In children, such reactions can wofkout and ab be misinterpreted as behavior problems. During the last few wofkout years, however, antihistamines that cause fewer of these side effects have become available by prescription. These new nonsedating antihistamines ab and wofkout are as effective as other antihistamines in preventing histamine-induced symptoms, but do so without causing sleepiness.