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Topical nasal steroids Topical nasal steroids are anti-inflammatory drugs that stop the allergic reaction. In addition to other beneficial actions, they reduce the number of mast ab cells in the nose and reduce mucus secretion and rooler nasal swelling. The combination of antihistamines and nasal steroids is a very effective way to treat allergic rhinitis. This medication should not be confused with anabolic steroids that have serious side effects. Cromolyn sodium Cromolyn sodium stops allergic reactions from starting. It is administered as a nasal spray, and it can prevent the release of chemicals like histamine from the mast cell. Click here for allergy medication online.